11

COUGH AND COLD

Clinical Evidence Comparable therapeutic benefit to Xylometazoline1

An effective, natural way to relieve symptoms of acute rhinitis and sinusitis1

References 1) Ammerschläger H, Klein P, Weiser M, Oberbaum M. Treatment of Infl ammatory Diseases of the Upper Respiratory Tract Comparison of

a Homeopathic Complex Remedy with Xylometazoline [in German]. Forschende Komplementärmed Klass Naturheilkd. 2005; 12: 24-31

Decrease in severity of illness with Euphorbium comp.1

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Before treatment

After treatment. Decrease in severity of illness with Euphorbium comp.

Differences with one-sided confidence intervals adjusted according to propensity scores and initial values; patients included in effectiveness analysis. Dose of Euphorbium compositum nasal spray 3-5x/day, xylometazoline: according to manufacturers recommendations; duration of treatment: 2.5 weeks.

Difference in reduction in symptoms studied between the therapeutic alternatives Euphorbium compositum nasal spray (n=252) and xylometazoline (n=250)4

Adapted from Ammerschläger et al.1

-4 -3 -2 -1 0 1 2 3 4

Interval of irrelevant difference

95% confidence interval (one-sided)

Difference between xylometazoline and Euphorbium compositum

Superiority of xylometazoline Superiority of Euphorbium compositum

Adapted from Ammerschläger et al.1