23MODE OF ACTION
Traumeel® regulates a number of gene ontologies in the interleukin family. One example amongst others is IL1-β. Traumeel® delays and attenuates the strong increase in IL1-β mRNA expression in the 12 24 hour period after wounding.[St Laurent 2017] (Figure 5). This is consistent with Traumeel s known action to reduce the pain of inflammation in other indications.[Schneider 2011, González de Vega 2013]
Transcriptomic studies have demonstrated that Traumeel® treatment modulates several major wound repair pathways.[St Laurent 2017, St Laurent 2021]
Early effects involved the wound repair and response to stress pathways.[St Laurent 2017]
Later effects tended to involve the wound contraction and anti-apoptotic pathways necessary for efficient wound closure.[St Laurent 2017]
Diclofenac, via effects upon the prostaglandin pathway, affected hundreds of transcripts, but in different cellular pathways.[St Laurent 2021]
In key pathways, such as the defense response and cell motility, diclofenac s effects were often opposite to that of Traumeel®.[St Laurent 2021]
Although Traumeel® and diclofenac share many inflammation-related pathways, diclofenac is more active at earlier proinflammatory stages, while Traumeel® is more active at a later wound healing stage.[St Laurent 2021]
Overall, genome-wide transcriptional analyses suggest that Traumeel® modulates different inflammatory processes than diclofenac with little overlap. It seems to be due to its multicomponent, multitargeted nature.[St Laurent 2017, St Laurent 2021]
Wound healing model
Actions of Traumeel® Traumeel® produced biologically significant and consistent changes in
hundreds of gene ontologies involved in wound healing.[St Laurent 2017]
Hundreds of differentially regulated gene ontologies compared to the saline control.[St Laurent 2017]
G en
e ex
pr es
si on
Tr14
Control
800
600
400
200
0 0 72362412 12096 192
Hours post-injury
IL1-β precursor
Figure 5 The effect of Tr14 on select transcripts in the interleukin pathway[St Laurent 2017]
