A full suite of immuno-depleted TriniCLOT Factor Deficient Plasmas for all the extrinsic and intrinsic factors is provided.

TriniCLOT Factor II, V, VII or X Deficient Human Plasma are intended for the quantitative determination of extrinsic factors in human plasma by clotting assay. TriniCLOT Factor VIII, IX, XI or XII Deficient Human Plasma are intended for the quantitative determination of intrinsic factors in human plasma by clotting assay.

TriniCLOT Factor VIII may also be used as a negative control in Von Willebrand Factor assays.

TriniCHROM FVIII:C

TriniCHROM FVIII:C is designed for the quantitative determination of Factor VIII:C in human plasma and Factor VIII concentrate by chromogenic assay.

Haemophilia A is a bleeding disorder caused by the deficiency of Factor VIII procoagulant activity (VIII:C). The quantitative determination of Factor VIII:C is useful in the diagnosis of Haemophilia A and in the determination of the severity of the disorder.

The arrival onto the market of new long-acting substitution FVIII therapies has made it necessary to develop new methods for quantitative determination of FVIII in human plasma, especially chromogenic assays.

Factor VIII:C is a blood plasma protein which exists as a complex with Von Willebrand factor. After activation by thrombin, Factor VIII:C acts as a cofactor in the conversion of Factor X to Factor Xa when calcium and phospholipid are present. The quantity of Factor Xa generated is determined using a specific chromogenic substrate and is directly proportional to the amount of Factor VIII:C in the sample.

PART NUMBER PRODUCT NAME PACKAGING STABILITY

T1502 TriniCLOT Factor II 10 x 1 mL 8 hours at 2-8°C

T1505 TriniCLOT Factor V 10 x 1 mL 8 hours at 2-8°C

T1507 TriniCLOT Factor VII 10 x 1 mL 8 hours at 2-8°C

T1508 TriniCLOT Factor VIII 10 x 1 mL 8 hours at 2-8°C

T1509 TriniCLOT Factor IX 10 x 1 mL 8 hours at 2-8°C

T1510 TriniCLOT Factor X 10 x 1 mL 8 hours at 2-8°C

T1511 TriniCLOT Factor XI 10 x 1 mL 8 hours at 2-8°C

T1512 TriniCLOT Factor XII 10 x 1 mL 8 hours at 2-8°C

PART NUMBER PRODUCT NAME PACKAGING STABILITY

T2608 TriniCHROM Factor VIII:C

Factor IXa Reagent: 3 x 1 mL 8 hours at 2-8°C

Factor X Reagent: 3 x 2 mL 7 days at 2-8°C

Factor Xa Substrate: 3 x 6 mL 7 days at 2-8°C

Dilution Buffer (10X): 3 x 5 mL 30 days at 2-8°C

PART NUMBER PRODUCT NAME PACKAGING STABILITY

T1901 TriniCLOT Imidazole Buffer 6 x 20 mL Until expiration date

T1902 TriniCLOT Calcium Chloride 0.025 M 10 x 10 mL Until expiration date

T1903 TriniCLOT Owren s Buffer 24 x 15 mL Until expiry date

Factor Deficient Plasmas

Solutions

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