TRAUMEEL® PRODUCT MONOGRAPH18

4 MODE OF ACTION

THERAPEUTIC INDICATIONS

Traumeel® is an effective treatment for acute processes of musculoskeletal disorders that involve inflammation, such as injuries or acute flare of chronic conditions. It is suitable for use in patients who require relief of symptoms associated with such injury.

It is indicated as a first-line treatment for patients with traumatic injuries of all kinds such as sprains, dislocations, contusions, hemarthrosis and effusions into a joint; regulation of inflammatory processes in various organs and tissues, including in particular acute and chronic/degenerative disorders of the musculoskeletal system.

INFLAMMATION RESOLUTION: A NEW THERAPEUTIC TARGET

Inflammation is a reaction of the host to infectious or sterile tissue damage and has the primary physiological purpose of restoring tissue homeostasis.[Medzhitov 2010, Nathan 2010] Uncontrolled or non-resolving inflammation can both lead to tissue damage, giving rise to a plethora of chronic inflammatory diseases, including metabolic syndrome and autoimmunity pathologies with eventual loss of organ function. Resolution protects the tissue and leads to homeostasis.

Latest research including single-molecule transcriptome sequencing demonstrates how a multicomponent, multitarget treatment can potentially promote inflammation resolution and tissue healing.[St Laurent 2021, St Laurent 2017] Recent clinical evaluations have supported the potential for Traumeel® to promote inflammation resolution and tissue healing in clinical practice.[Das 2019, Helei 2019]

Inflammation resolution is a critical process The inflammatory response has defined phases involving different sets of mediators and cell types. In the initiation phase proinflammatory mediators initiate the inflammatory cascade in response to injury or infection. Next, inflammation transitions towards resolution and proinflammatory as well as proresolution mediators are present. Resolution is ongoing when other sets of mediators dictate events that terminate the inflammatory process and fully engage in resolution. [Serhan 2005, Sugimoto 2016, Sugimoto 2019]

Inflammation resolution is not merely a passive cessation of proinflammatory mechanisms. It is a complex, tightly regulated system of processes that is critical for tissue healing and restoration of function. Important elements include:[Sugimoto 2016, Serhan 2014, Feehan 2019, Jones 2016, De Oliveira 2016]

Neutrophil influx: swarming of neutrophils from the blood stream into the injury site

Lipid mediator class switch: release of proresolving mediators, such as lipoxins, resolvins, protectins and maresins