3CONTENTS

CONTENTS

1 Overview 5 2 Musculoskeletal disorders 7 Musculoskeletal injuries 7 Epidemiology of musculoskeletal injury 7 Classification of musculoskeletal injuries 8 Tissue response to acute injury 8 Factors affecting response to injury 9 Current treatment options 9 Summary 12 Osteoarthritis 12 Role of inflammation 14 Zeel® T 15 Traumeel® and Zeel® T 15 Summary 15 3 Composition 16 4 Mode of action 18 Therapeutic indications 18 Inflammation resolution: a new therapeutic target 18 Inflammation resolution is a critical process 18 Treatments that suppress inflammation may also suppress

its resolution 19 Atlas of inflammation resolution (AIR) 25 How is the AIR organized? 26 Summary 27 5 Traumeel® Studies Indications 28 6 Clinical studies 30 Randomized controlled clinical trials 30 Topical Traumeel® vs. diclofenac gel: Treatment of acute sprains

of the ankle: TAASS 30 Topical Traumeel® vs. Placebo: Treatment of acute sprains of the ankle 34 Topical Traumeel® vs. Placebo: Treatment of acute

musculoskeletal injuries 36 Traumeel® in co-administration with Zeel® T (intra-articular injections)

for the treatment of knee osteoarthritis: the MOZArT study 38 Non-randomized observational studies 42 Traumeel® compared with conventional therapy in the treatment

of injuries 42 Traumeel® compared with diclofenac 1% gel for acute symptomatic

treatment of tendinopathy 44 Traumeel® compared with NSAIDs for symptomatic treatment

of epicondylitis 46 Surveillance studies 48 Drug surveillance for Traumeel® ointment 48 Drug surveillance for Traumeel® injection 50 Drug surveillance for Traumeel® oral treatment 52