69SUMMARY

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Lozada CJ, del Rio E, Reitberg DP, et al. A double-blind, randomized, saline-controlled study of the efficacy and safety of co-administered intra-articular injections of Tr14 and Ze14 for treatment of painful osteoarthritis of the knee: the MOZArT trial. Eur J Integr Med. 2017;13:54 63.

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Zenner S, Metelmann H. Application possibilities of Traumeel® S injection solution: results of a multicentric drug monitoring trial conducted on 3,241 patients. Biol Ther. 1992;X(4):301 310.

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TRAUMEEL® HAS A WELL-ESTABLISHED EFFICACY, EFFECTIVENESS AND SAFETY PROFILE

In vitro Complex regulation of the inflammation process

(granulocytes, lymphocytes, platelets and endothelial cells) [Cesnulevicius 2011]

Effects on resolution phase of acute inflammation [Jordan 2021]

Clinical surveillance and observational Drug surveillance for Traumeel® injection

[Zenner 1992] Drug surveillance for Traumeel® ointment

[Zenner 1994] Drug surveillance for Traumeel® oral

treatment [Zenner 1997] Observational study Traumeel® vs

conventional therapies [Schneider 2008]

In vivo Acute and chronic inflammation, edema

(swelling and local inflammation) [Lussignoli 1999, Conforti 1997]

Gene expression changes in inflammation (wound-healing model) [St Laurent G 3rd 2017]

RNAseq analysis of treatment-dependent signaling changes [St Laurent G 2021]

Biosynthesis of SPMs [Jordan 2021]

Clinical vs NSAIDs vs diclofenac gel [González de Vega 2013,

Schneider 2005] and injectable NSAIDs [Birnesser 2004]

Tendinopathy, [Schneider 2005] epicondylitis [Birnesser 2004] and ankle sprain [González de Vega 2013]

Clinical vs placebo Acute sprains of the ankle [Zell 1989] Acute musculoskeletal injuries

[Böhmer 1992] Knee osteoarthritis (+ Zeel® T) [Lozada 2017]

Figure 24 Traumeel® efficacy, effectiveness and safety profile